Size matters: gold nanoparticles in targeted cancer drug delivery

Gold nanoparticles stabilize peptide-drug-conjugates for sustained targeted drug delivery to cancer cells

BACKGROUND Peptide-drug-conjugates (PDCs) are being developed as an effective strategy to specifically deliver cytotoxic drugs to cancer cells. However one of the challenges to their successful application is the relatively low stability of peptides in the blood, liver and kidneys. Since AuNPs seem to have a longer plasma half-life than PDCs, one approach to overcoming this problem would be to ...

Advances in Targeted Drug Delivery

Advances in Targeted Drug Delivery

Size matters: nanoparticles in cancer therapy

Multimodal drug delivery using gold nanoparticles.

Gold nanoparticles (AuNPs) are promising nanocarriers for therapeutics due to their facile synthesis, ease of functionalization, biocompatibility, and inherent non-toxicity. The unique chemical and physical properties of AuNP monolayers provide versatility in delivery method and tunability of surface properties. Here, we discuss several strategies to utilize the properties of AuNPs for drug del...